Wakefield Research

Vascular Interventions/Innovations and Therapeutic Advances (VITA)
          Wakefield TW and Sood, Suman      11/15/2013 – 11/14/2016
A Phase 1 study to assess the safety and pharmacokinetics of GMI-1271 in healthy adult subjects and calf vein DVT

Novel Therapeutic Targets for Venous Thromboembolism
This project will determine the role of VWF and P-selectin in venous thrombosis in various animal models and in primates. We will also develop new agents to target these molecules for the prevention and treatment of venous thrombosis.

University of Michigan Stanley and Jean Frankel Cardiovascular Center Inaugural Grant    Sood, Suman and Wakefield, TW    07/01/2013 – 06/30/2014
“An External Validaiton Study of Novel Biomarkers to Predict Deep Venous Thrombosis (DVT and Pulmonary Embolism (PE)”

2T32 HL076123  Wakefield, TW, PI0           9/01/2009 – 08/31/2014
Vascular Surgery: Research Training in Vascular Biology (T32) – Renewal  
No overlap to current project.
Role: Consultant 

PPG, (Lawrence, PI)                            04/01/08 - 03/31/13        
Novel Targets in Thrombosis and Atherosclerosis
Core A: Animal Model Core                   
The purpose of the Animal Model Core A is to provide each investigator of the PPG a wide variety of animal models to assess lipid metabolism, thrombosis, and related vascular disorders.
Role: Project Director

NIH                                                   04/01/07-03/31/12           
K01 HL08962-01 (Myers, PI)                                                            
"Free Radicals Influence the Pathogenesis of Venous Thrombosis”
The project is a mentored minority award and will study the role of free radicals in various models of venous thrombosis.
Role: Mentor

2 RO1 HL070766-05A2, Wakefield (PI)    12/01/2006-11/30/2011         
Procoagulant Microparticles: Novel Determinants of Venous Thrombogenesis
This project focuses on the role of microparticles in venous thrombogenesis                     
This project will evaluate the role of P-selectin in the pathogenesis of venous thrombosis.
No overlap to the current project.

RO1 HL083918,  Henke (PI)                    04/01/2006-03/31/2010        
“Vein Wall Remodeling After Deep Vein Thrombosis (DVT) is Matrix Metalloproteinase-Dependent”
This project tests the hypothesis that prolonged or exaggerated leukocyte derived MMP-9 activity will have greater expression early, as well as correlate with long term severity of venous insufficiency.
Role: Co-Investigator

Wyeth (Wakefield, PI)                            01/01/06-12/20/07                          
Inhibition of Venous Thrombosis and Inflammation by a PAI-1 Inhibitor in a Non-Human Primate
This project evaluates new agents to inhibit thrombosis is primate models of venous thrombosis.

RO1 (Weg, PI; Subcontract of Stein, P PI)   08/01/2005-05/31/2009               
Prospective Investigation of Pulmonary Embolism Dx III    
This project will investigate the utility of MR imaging in the diagnosis of pulmonary embolism.
No overlap to current project
Role: Ultrasound Chair

RO1   (Leonard, PI)                            09/01/04-08/31/09     
Amputation Surgery and Prosthetic Education
This project will develop a training program to improve patient care after amputation surgery.
No overlap to current project.
Role: Consultant

1 T32 HL076123-01 (Wakefield, PI)        04/01/04-03/31/09       
NIH Training and Special Programs                                                          
Vascular Surgery: Research Training in Vascular Biology
This project establishes a training grant for Vascular Biology, encompassing faculty from multiple disciples.  The common theme is an emphasis on the basic study of vessel wall biology and vascular pathology with the ultimate goal to produce the next generation of leaders in academic vascular sciences.